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If you have previously taken EXMD 609 you must select a topic significantly different from the one you chose for that course. Not more than one student can select any given topic. Topics in italicized red font have already been selected.
- Calcium imaging in live animals (Caitlin Anderson)
- Genetically-encoded biosensors for intracellular molecules
- Chiral chromatography
- Purification of subcellular organelles for proteomic analysis
- Atomic force microscopy
- Stimulated emission depletion (STED) microscopy
- Intravital microscopy
- Spinning disk confocal microscopy
- Multiphoton microscopy
- Biological applications of total internal reflection fluorescence microscopy
- Applications of Raman scattering microscopy in biomedical research
- Lensless on-chip microscopy and its biomedical applications
- Biomedical applications of focused ion beam microscopy
- Tissue imaging using mass spectrometry
- Nano and micro computed tomography
- Use of optical tweezers to investigate the properties of molecular motors
- Use of surface plasmon resonance for the study of protein-protein interactions
- Use of dynamic mass redistribution to evaluate intracellular signaling responses
- Generation of genetically engineered animals for food: Methods, controversies and justifications (Claudia Dominici)
- Recent progress in in vivo genome editing: Methods, comparative discussion and implications on health research (Lauren Nagel)
- Chromatin immunoprecipitation (ChIP) (Herthana Kandasamy)
- Tools to investigate miRNA expression and function
- Recently-developed methods for the in vitro transfection of cells (excluding calcium phosphate & standard lipofection) (Michael Bruccoleri)
- Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase (DamID) (Karla Paez Martinez)
- Chromosome conformation capture methodology
- The use of transposons to study gene functions
- Exome sequencing
- Single-cell transcriptomics (Samantha Worme)
- In situ sequencing: sequencing genetic material directly from intact tissues
- Probes for real-time detection and perturbation of cellular signaling (George Dong)
- Bioinformatic methods used to understand gene expression regulation in systems biology approaches
- Genome-wide association studies
- Identification of protein interactions using phototrapping and photocrosslinking
- Use of tandem affinity purification (TAP) for the identification of protein interactions
- Determination of the biosynthetic pathways of small peptides
- Methods used to study the internalization and fate of cell membrane receptors
- Use of NMR in protein characterization
- Characterization of proteins by X-ray crystallography
- Investigation of protein dynamics using time-resolved X-ray crystallography
- Investigation of conformational changes in proteins using ultrafast X-ray free-electron lasers
- Determination of protein structure using single-particle cryo-electron microscopy
- High throughput methods to identify receptor onists (Ahmed Fouda)
- Recent methods for drug delivery and targeting (Yuan Cao)
- Gene therapy (Hetaben Patel)
- DNA vaccines (Surbhi Kedia)
- Dendritic cell vaccines
- Oncolytic viruses in cancer therapy (Aymane Deiri)
- Use of adoptive cell transfer in biomedical research
- Biomedical applications of 3D printing (Jordan Kruisselbrink)
- Scaffolds and cells for tissue engineering
- Intracellular probes to measure oxidative stress
- Methods used to assess angiogenesis (Martin Karam)
- Applications of ribozymes in medical research
- Biomedical applications of quantum dots
- Biomedical applications of magnetic nanoparticles (Rhythm Sharma)
- Mapping of neural circuits (Peter Jeon)
- Experimental treatment of disease by transplantation of neuronal cells (Sara Sedaghat)
- Optogenetics and its applications
- Production and applications of organoids (Arash Samiei)
- "Disease in a dish" using induced pluripotent stem cells
- Organs on chips to model human diseases (Raidan Alyazidi)
- Single cell mass cytometry (Joey Heath)
- Use of gene drives to target mosquito-borne diseases: methodology, current progress and ethical issues
- Epitranscriptome analysis
- Biomedical and therapeutic applications of aptamers (Sam Kajjo)
- Biomedical and therapeutic applications of focused ultrasound (Taraneh Rafiezadeh)
- Targeting RNA using CRISPR (Sahar Mikaeeli)
- The use of Genome-wide CRISPR-screening to study cellular functions (Steven Findlay)
- In silico approaches to drug development
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